Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis
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Abstract Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic HTLV-1 infection, and the tumors carry both somatic mutations and proviral DNA integrated into the tumor genome. In order to gain insight into the oncogenic...
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Evolution , LONG-TERM , T-Lymphocytes , Mononuclear , Immunology , 610 , LYMPHOCYTES , DISEASE , Evolution, Molecular , Leukocytes , LEUKEMIA-LYMPHOMA , Humans , Leukemia-Lymphoma, Adult T-Cell , Adult T-Cell , Longitudinal Studies , 1102 Cardiorespiratory Medicine and Haematology , RISK , Human T-lymphotropic virus 1 , Science & Technology , Molecular , 1103 Clinical Sciences , Hematology , SOMATIC MUTATIONS , MONOCLONAL PROLIFERATION , CANCER , HTLV-I Infections , United Kingdom , Clone Cells , SURVIVAL , Leukocytes, Mononuclear , 1114 Paediatrics and Reproductive Medicine , Life Sciences & Biomedicine , HTLV-1 CARRIERS