Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination
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Yersinia pestis is a Gram‐negative bacterium that causes plague. After Y. pestis overcomes the skin barrier, it encounters antigen‐presenting cells (APCs), such as Langerhans and dendritic cells. They transport the bacteria from the skin to the lymph nodes. However, the molecular mechanisms involved in bacterial transmission are unclear. Langerhans cells...
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Dendritic Cells/metabolism , Langerhans Cells/metabolism , Yersinia pestis/metabolism , C-Type/immunology* , Cell Surface/immunology , Bacterial Adhesion , O-ANTIGEN , Mice , CORE LIPOPOLYSACCHARIDE , Antigen-Presenting Cells/microbiology , Lectins , Cricetinae , Receptors , O Antigens/metabolism , Cells, Cultured , O Antigens/immunology , 106022 Mikrobiologie , Cultured , Protein Binding/immunology , HIV-1 TRANSMISSION , CD/immunology* , CD/metabolism , O Antigens , Bacterial Adhesion/immunology , Flow Cytometry , Host-Pathogen Interactions/immunology , Plague/microbiology , Plague/immunology , Host-Pathogen Interactions , 106022 Microbiology , NEISSERIA-GONORRHOEAE , Protein Binding , 570 , ESCHERICHIA-COLI K-12 , Langerhans Cells/immunology , Cells , Cell Surface/metabolism , 610 , Antigen-Presenting Cells , RFB GENE-CLUSTER , CHO Cells , DENDRITIC CELLS , Cricetulus , Phagocytosis , Antigens, CD , Animals , Humans , Lectins, C-Type , Antigens , PLASMINOGEN-ACTIVATOR , Mannose-Binding Lectins/metabolism , C-Type/metabolism , Plague , Yersinia pestis/immunology* , DC-SIGN CD209 , Phagocytosis/immunology* , Original Articles , Dendritic Cells , Survival Analysis , Biomedicine , Mannose-Binding Lectins , Dendritic Cells/immunology , Mannose-Binding Lectins/immunology* , Langerhans Cells , MONOCLONAL-ANTIBODIES , Antigen-Presenting Cells/immunology* , Yersinia pestis/physiology