Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
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AbstractThe electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified...
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Male , Multifactorial Inheritance , Supplementary Data , EMC NIHES-03-77-01 , Arrhythmias, Cardiac / physiopathology , General Physics and Astronomy , Gene Expression , Arrhythmias , Cardiovascular , Genome-wide association studies , Public health care science, environmental and occupational health , Medical Genetics and Genomics , CALCINEURIN , Electrocardiography , info:eu-repo/classification/ddc/616 , Cardiovascular Disease , name=General Biochemistry,Genetics and Molecular Biology , ELEMENTS , 2.1 Biological and endogenous factors , GWAS , Cardiac and Cardiovascular Systems , Aetiology , Cardiovascular Diseases / physiopathology , cardiovascular genetics , Genetic Loci / genetics , RISK , DECREASE , /dk/atira/pure/subjectarea/asjc/1300/1300 , Kardiologi , Q , R , Biological Sciences , Medicinsk genetik och genomik , Endophenotype , Heart Disease , Cardiovascular diseases , Arrhythmias, Cardiac; Cardiovascular Diseases; Endophenotypes; Female; Gene Expression; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Humans; Male; Multifactorial Inheritance; Quantitative Trait Loci; Electrocardiography , name=General Physics and Astronomy , Genetics, developmental biology, physiology , Cardiovascular Diseases , Female , Medical Genetics , Cardiac , /dk/atira/pure/subjectarea/asjc/1600/1600 , Cardiology and Cardiovascular Disease , Biotechnology , Cardiovascular Diseases / genetics , Human , Endophenotypes , Science , General Biochemistry,Genetics and Molecular Biology , DURATION , EMC OR-01 , GENOME-WIDE ASSOCIATION ; ATRIAL-FIBRILLATION ; MUTATIONS ; RISK ; DURATION ; CARDIOMYOPATHY ; CALCINEURIN ; BRADYCARDIA ; DECREASE ; ELEMENTS , Quantitative Trait Loci , 610 , R Medicine , Quantitative Trait Loci / genetics , Article , SDG 3 - Good Health and Well-being , Kardiologi och kardiovaskulära sjukdomar , Genetics , Humans , Genetic Predisposition to Disease , GENOME-WIDE ASSOCIATION , Medicinsk genetik , CARDIOMYOPATHY , Biomedical and Clinical Sciences , MUTATIONS , Human Genome , Arrhythmias, Cardiac / genetics , Genetic Variation , Arrhythmias, Cardiac , General Chemistry , Cardiovascular genetics , Genetic Predisposition to Disease / genetics , cardiovascular diseases , Good Health and Well Being , Genetic Loci , genome-wide association studies , ATRIAL-FIBRILLATION , BRADYCARDIA , /dk/atira/pure/subjectarea/asjc/3100/3100 , name=General Chemistry , Genome-Wide Association Study