Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data
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AbstractIndividuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies (GWASs) to determine if commonly...
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Crohn’s disease , rheumatoid arthritis , Male , Medicine (General) , Multifactorial Inheritance , Databases, Factual , type 1 diabetes , Obsessive Compulsive and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium , linkage disequilibrium score regression , Clinical sciences , Comorbidity , anorexia nervosa , Linkage Disequilibrium , immune-related disorders , single nucleotide polymorphisms , Congenital , systemic lupus erythematosus , GWASs , 2.1 Biological and endogenous factors , neuroticism , genome‐wide association , Pediatric , bipolar disorder , LDSC , Mental Disorders , and Me Research Team , METASTROKE Consortium of the International Stroke Genetics Consortium , bioinformatics , Pharmacology and Pharmaceutical Sciences , Single Nucleotide , neuroCHARGE Working Group , Biological Sciences , Serious Mental Illness , Mental Illness , genetic correlation , C‐reactive protein , Crohn's disease , psychiatric disorders , Hereditary , Mental Health , Immune System Diseases , obsessive schizophrenia , attention deficit‐hyperactivity disorder , Mental health , Female , Genetic Phenomena , Medical Genetics , SNPs , Clinical Sciences , 610 , Autoimmune Disease , Polymorphism, Single Nucleotide , smoking , White People , C-reactive protein , Autoimmune Diseases , Databases , childhood ear infection , Health Sciences , 616 , Behavioral and Social Science , Genetics , Humans , Genetic Predisposition to Disease , Polymorphism , Factual , tuberculosis susceptibility , Inflammation Working Group of the CHARGE Consortium , ulcerative colitis , Population Biology , Biomedical and Clinical Sciences , Tourette syndrome , Inflammatory and immune system , Human Genome , Neurosciences , Genetics and Genomics , attention deficit-hyperactivity disorder , allergy , Brain Disorders , primary biliary cirrhosis , genome-wide association studies , Netherlands Twin Registry , Schizophrenia , genome-wide association , hypothyroidism , autoimmune disorder , major depression , celiac disease , and Neonatal Diseases and Abnormalities , Genome-Wide Association Study