Wiley Online Library User AgreementChristina C. DahmHeather WardElisabete WeiderpassAlexandra VulcanJosé María HuertaRoel VermeulenSabina SieriMazda JenabCristina LasherasMarc J. GunterCecilie KyrøGenevieve BucklandPaula JakszynKonstantinos K. TsilidisEva ArdanazElio RiboliAurora Perez-CornagoYahya Mahamat-SalehMarie-Christine Boutron-RuaultHeather WardRosario TuminoGuri SkeieGiovanna MasalaFulvio RicceriPilar AmianoHeiner BoeingBodil OhlssonValerie CayssialsVerena KatzkeDorthe NyvangAntonia TrichopoulouAntonio AgudoAmanda J. CrossEleni PeppaAnne TjønnelandFranck CarbonnelAnna KarakatsaniKonstantinos K. TsilidisTilman KühnSalvatore PanicoMaría José SánchezManuela M. BergmannYahya Mahamat-Saleh2025-06-192025-06-192020-01-310020-71361097-021510.1002/ijc.32870https://ror.circle-u.eu/handle/123456789/1260003<jats:p>Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite‐ and sex‐specific associations. The relationship between CRC and combined lifestyle‐related factors that contribute toward a low‐grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed‐up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest <jats:italic>versus</jats:italic> lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04–1.27) for CRC, 1.24 (95% CI 1.09–1.41) for colon cancer and 0.99 (95% CI 0.83–1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest <jats:italic>versus</jats:italic> lowest IPS was 1.62 (95% CI 1.31–2.01) for colon cancer overall and 2.11 (95% CI 1.50–2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.</jats:p>OPENMaleDietèticaObesidadCohort StudiesMARKERSNeoplasias colorrectalesRisk FactorsTaverneAnálisis de regresiónEstudios prospectivosATHEROSCLEROSIS MAASTRICHT CODAMProspective StudiesLOW-GRADE INFLAMMATIONINDEXInvestigació prospectivaGLUCOSE-METABOLISMASSOCIATIONMiddle AgedEjercicio físicoC-REACTIVE PROTEINEuropeOncologyCòlon -- Càncerinflammatory potential of the diet/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingRegression AnalysisepidemiologyDietaFemaleEuropaColorectal NeoplasmsLife Sciences & BiomedicineAdultConducta alimentariaEstudios de cohortesprospective cohort610[SDV.CAN]Life Sciences [q-bio]/Cancercolorectal cancer613MECHANISMSAssociationSDG 3 - Good Health and Well-beingCOLON616Análisis multivarianteHumans1112 Oncology and CarcinogenesisOncology & CarcinogenesisObesityInflammatory potential of the dietEpidemiologiaExerciseInflammationScience & TechnologyInflamaciónassociation; colorectal cancer; epidemiology; Europe; inflammatory potential of the diet; prospective cohortassociationDieta proinflamatoriaFeeding Behaviorname=SDG 3 - Good Health and Well-beingDietPHYSICAL-ACTIVITYNutrition AssessmentMultivariate Analysispublication0301 basic medicine03 medical and health sciences2. Zero hunger3. Good healthdoi_dedup___:e756f9f99edf97e8f7a070070f4793f03194519910668/1496120.500.14342/38931983/948c4c54-fcf5-4300-80c9-482250416be62318/176647610044/1/76406