CC BY NC NDAnton PottegårdSidsel Arnspang PedersenLisbet Rosenkrantz HölmichDavid GaistSigrún Alba Jóhannesdóttir SchmidtSøren FriisSidsel Arnspang Pedersen2025-06-172025-06-172018-04-010190-962210.1016/j.jaad.2017.11.042https://ror.circle-u.eu/handle/123456789/932198Hydrochlorothiazide, one of the most frequently used diuretic and antihypertensive drugs in the United States and Western Europe, is photosensitizing and has previously been linked to lip cancer.To examine the association between hydrochlorothiazide use and the risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).From the Danish Cancer Registry, we identified patients (cases) with nonmelanoma skin cancer (NMSC) during 2004-2012. Controls were matched 1:20 by age and sex. Cumulative hydrochlorothiazide use (in 1995-2012) was assessed from the Danish Prescription Registry. Using conditional logistic regression, we calculated odds ratios (ORs) for BCC and SCC associated with hydrochlorothiazide use.High use of hydrochlorothiazide (≥50,000 mg) was associated with ORs of 1.29 (95% confidence interval [CI], 1.23-1.35) for BCC and 3.98 (95% CI, 3.68-4.31) for SCC. We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (≥200,000 mg of HCTZ) had ORs of 1.54 (95% CI, 1.38-1.71) and 7.38 (95% CI, 6.32-8.60) for BCC and SCC, respectively. Use of other diuretics and antihypertensives was not associated with NMSC.No data on sun exposure were available.Hydrochlorothiazide use is associated with a substantially increased risk of NMSC, especially SCC.OPENMaleSquamous Cell/chemically inducedHydrochlorothiazide/adverse effectspharmacoepidemiologySkin NeoplasmsCarcinoma, Squamous Cell/chemically inducedDenmarkcancer riskBasal Cell/chemically inducedRisk Assessmentpharmaco-epidemiology80 and overJournal ArticleHumansantihypertensivesAntihypertensive AgentsAgedAged, 80 and overskin cancerCarcinomaAntihypertensive Agents/adverse effectsMiddle AgedSkin Neoplasms/chemically inducedhydrochlorothiazideDenmark/epidemiologyCarcinoma, Basal Cell/chemically inducedHydrochlorothiazideCarcinoma, Basal CellCase-Control StudiesCarcinoma, Squamous Cellnonmelanoma skin cancerFemalepharmacologypublication03 medical and health sciences0302 clinical medicine3. Good healthdoi_dedup___:a578e3c2877b5f4ae48af119a4838ecf29217346