Alterations in Amygdala-Prefrontal Functional Connectivity Account for Excessive Worry and Autonomic Dysregulation in Generalized Anxiety Disorder
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Abstract
Generalized anxiety disorder (GAD) is characterized by the core symptom of uncontrollable worry. Functional magnetic resonance imaging studies link this symptom to aberrant functional connectivity between the amygdala and prefrontal cortex. Patients with GAD also display a characteristic pattern of autonomic dysregulation. Although frontolimbic circuitry is implicated in the regulation...
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Adult , Male , Prefrontal Cortex , Amygdala , Anxiety Disorders , Magnetic Resonance Imaging , Young Adult , Autonomic Nervous System Diseases , Heart Rate , Connectome , Humans , Female , amygdala; functional connectivity; functional magnetic resonance imaging; generalized anxiety disorder; heart rate variability; perseverative cognition; biological psychiatry