Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
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AbstractFew genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as...
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Netherlands Twin Register (NTR) , Epidemiology , 201668 , RG/10/12/28456 , Arthritis Research UK (ARUK) , Body Mass Index , LSHG-CT-2006-018947 , name=General Biochemistry,Genetics and Molecular Biology , IMPUTATION , 284167 , POPULATION , Adiposity , 018996 , 230374 , HEALTH-F2-2008-201865-GEFOS , genetics [Smoking] , ASSOCIATION , 1600 Chemistry , name=General Physics and Astronomy , 305739 , Science & Technology - Other Topics , ddc:500 , Waist Circumference , RG2008/014 , /dk/atira/pure/subjectarea/asjc/1600/1600 , European Research Council , genetics [Adiposity] , H Social Sciences (General) , 018947 , 330 , G0601966 , Science , Quantitative Trait Loci , 610 , ta3111 , Article , LSHM-CT-2006-037697 , * , SP/04/002 , IMI/115006 , Genetic , SDG 3 - Good Health and Well-being , GWAS, obesity, smoking , 616 , HEALTH-2011-294713-EPLORE , Humans , Polymorphism , Science & Technology , genetics [Quantitative Trait Loci] , QLG2-CT-2002-01254 , 323195:SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC , Epistasis, Genetic , ta3121 , R1 , BBMRI-LPC-313010 , HEALTH-2011.2.4.2-2-EU-MASCARA , genetics research , MC_U106179471 , General Biochemistry , Epistasis , /dk/atira/pure/subjectarea/asjc/3100/3100 , Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all) , British Heart Foundation , obesity , Medicin och hälsovetenskap , RG2008/08 , General Physics and Astronomy , R Medicine (General) , methods [Genome-Wide Association Study] , HEALTH-F4-2007-201550-HYPERGENES , Medical and Health Sciences , Genome-wide association studies , LSHG-CT-2006-01947 , Public health care science, environmental and occupational health , G0000934 , genetics [Obesity] , Genetics research , Body Fat Distribution , 3100 Physics and Astronomy , genetics [Genetic Predisposition to Disease] , OXIDATIVE STRESS , METABOLIC SYNDROME , LSHM-CT-2004-005272 , /dk/atira/pure/subjectarea/asjc/1300/1300 , Q , Smoking , 223004 , Public Health, Global Health, Social Medicine and Epidemiology , Single Nucleotide , General medicine, internal medicine and other clinical medicine , Multidisciplinary Sciences , DEFICIENCY , ADDICTION , Phenotype , HEALTH-F2-2013-601456 , Adult , 1300 Biochemistry , HEALTH-F7-305507 HOMAGE , General Biochemistry,Genetics and Molecular Biology , genetics [Waist Circumference] , Genetics and Molecular Biology , QH426 Genetics , HEALTH-F4-2007-201413 , Polymorphism, Single Nucleotide , MD Multidisciplinary , Journal Article , Genetic Predisposition to Disease , Obesity , European Commission , National Institute for Health Research (NIHR) , EMC ONWAR-01-58-02 , VITAMIN-C , Waist-Hip Ratio , QLG1-CT-2002-00896 , G0701863 , General Chemistry , GENE , 279143 , HEALTH-2011-278913 , Medical Research Council (MRC) , Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi , MICE , LSHM-CT-2007-037273 , MC_UU_12019/1 , genome-wide association studies , Cancer Research UK , G0700931 , name=General Chemistry , Developmental Psychopathology , Genome-Wide Association Study