Increased incidence of seronegative autoimmune hepatitis in children during SARS-CoV-2 pandemia period
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BackgroundSeronegative autoimmune hepatitis in children is a rare but potentially severe disease, sometimes requiring liver transplantation. This type of hepatitis may be associated with various immunological and hematological disorders, ranging from isolated lymphopenia to aplastic anemia. Precise pathophysiological mechanisms are still unknown, but the role of viruses cannot be excluded,...
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Male , acute liver failure AST , bone marrow aspiration/biopsy , ALT , polymerase chain reaction , [SDV]Life Sciences [q-bio] , PT , PR , aspartate aminotransferase , LT , BMA/B , Severe Acute Respiratory Syndrome Coronavirus 2 SAIH , magnetic resonance imaging , alanine aminotransferase ALF , Epstein-Barr virus FV , hematopoietic stem cell transplantation Ig , Child , gamma-glutamyl transpeptidase , liver transplantation , Incidence , magnetic resonance imaging PCR , CMV , immunosuppressive treatment , Severe Acute Respiratory Syndrome Coronavirus 2 , coagulation factor V GGT , coagulation factor V , Hepatitis, Autoimmune , PCR , Seronegative autoimmune hepatitis WHO , Child, Preschool , HSCT , hematopoietic stem cell transplantation , pediatric seronegative autoimmune hepatitis , Female , hemoglobin HSCT , partial remission SARS-CoV-2 , CR , Immunosuppressive Agents , MRI , severe acute respiratory syndrome coronavirus 2 , Ig , aplastic anemia , Adolescent , complete remission , alanine aminotransferase , Immunology , aspartate aminotransferase ATG , partial remission , SAIH , liver transplantation LTd , EBV , bone marrow aspiration/biopsy CMV , LTd , gamma-glutamyl transpeptidase Hb , Epstein-Barr virus , Humans , cytomegalovirus CR , complete remission EBV , FV , AST , cytomegalovirus , Retrospective Studies , liver transplanted patients , SARS-CoV-2 , Hb , Antithymocyte Globulin BMA/B , prothrombin time PR , dysimmunity , polymerase chain reaction PT , COVID-19 , Infant , acute liver failure , hemoglobin , liver transplanted patients MRI , RC581-607 , AA , prothrombin time , GGT , immunoglobulin LT , ATG , Antithymocyte Globulin , ALF , World Health Organization pediatric seronegative autoimmune hepatitis , aplastic anemia ALT , Immunologic diseases. Allergy , immunoglobulin